| Database ID |
346 |
| Title |
Feasibility of clinical trials of therapeutic cocaine vaccines |
| Description |
To assess the feasibility of conducting clinical trials of cocaine vaccines in Australia |
| Status |
Archived |
| Researchers |
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| Keywords |
cocaine; dependency; prevention; economic aspects; liberature reviews |
| Methodology |
Review of the literature and an assessment of the progress of current clinical trials in humans including unpublished reports and data.
|
| Institution |
National Drug and Alcohol Research Centre |
| End Date |
06-2003 |
| Publications |
- Shearer, J & Mattick, RP (2003), Feasibility, rationale and prospects for therapeutic cocaine vaccines, Technical Report No 168, National Drug and Alcohol Research Centre, Sydney.
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| Contact |
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| Note |
Results:
The cost associated with the production of cocaine vaccines is considerable and several vaccine candidates have failed due to difficulties in achieving commercial scale production. The burden of disease in Australia associated with cocaine-related disorders may not be sufficient to justify the substantial investment required to conduct large scale original research studies into cocaine vaccines. Research into vaccines targeted towards other drugs of dependence such as nicotine may be more viable in the Australian context. Vaccines are unlikely to completely block cocaine effects or act as stand-alone treatments, but they may be a valuable additional therapeutic pathway in conjunction with psychosocial and pharmacological approaches.
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| Indexed |
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